SEDATIVE MEDICATIONS IN ICU – THEIR ROLES & EFFECTS

two. Histamine Receptor Antagonism: Some sedatives, for instance antihistamines, exert their sedative effects by blocking histamine receptors while in the brain, specifically H1 receptors. Histamine plays a role in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness.With regards to the drug and whether it's safe or not